Uses of Orlistat

Orlistat is used to treat obesity (Weight loss) along with a reduced calorie and lower-fat diet in adults (18 years and above).

Therapeutic Category

Orlistat: Anti-obesity drugs

How Orlistat works

Orlistat works by attaching to the enzymes in your digestive system (lipases) and preventing them from breaking down some of the fat that you’ve consumed during your meal. The fat that is not digested cannot be absorbed and it is removed by your body.

Common side effects of Orlistat

• flatulence with or without oily spotting
• sudden bowel motions
• fatty or oily stools
• soft stools
• stomach pain
• fecal incontinence
• runny or liquid stools
• more frequent bowel motions
• anxiety
• headache
• respiratory tract infection
• low blood sugar levels
• flu infection
• rectal pain or discomfort
• tooth or gum disorders
• urinary tract infection
• irregular menses
• tiredness

When to consult your doctor

Consult your doctor if you experience:

• severe allergic reactions (severe breathing problems, sweating, rash, itching, swollen face, rapid heartbeat, nausea, vomiting, feeling unwell)
• In case of accidental overdosage or ingestion

Health Tips for Orlistat

• Orlistat works best when combined with a reduced-calorie, balanced diet that contains moderate amounts of fat, carbohydrates, and protein. It is not a license to consume large amounts of high fat foods
• Drink plenty of water throughout the day to stay hydrated, especially if you experience diarrhea as a side effect of Orlistat
• Take Orlistat at the same time each day to maintain a consistent level of the medication in your system
• Orlistat is not recommended for use in pregnant and breast feeding women
• Orlistat can reduce the absorption of fat-soluble vitamins (A, D, E, K) and beta-carotene. To ensure you are getting adequate nutrients, consider taking a multivitamin supplement at least 2 hours before or after taking Orlistat

Also, see the tips for consuming Orlistat for better results -.

Try to take Orlistat at the same time each day to ensure to maintain a consistent level of the medication in your system, to avoid potential side effects

Make sure to include a full fruit daily family tree ( fruits, berries, Caul genomes fruit ) when taking Orlistat for obesity management. This may be helpful for reducing the risk of side effects or delay onset of other medications that can occur with Orlistat intake

Try to take Orlistat at the same time each day for a minimum of 3 days per week, as anticipated. If you experience side effects, try drinking a reduced-calorie, low-PI diet that doesn't contain fat, carbohydrates, and protein as a side effect. This does not contain fat and should be avoided

Try to take Orlistat as early as possible after eating, as some Orlistat-naive foods require prior knowledge of to be eliminated from your diet before they can be ingested by your body.

Xenical 120mg Capsules,when used in conjunction with a reduced-calorie diet, can be used for obesity management, including weight loss and weight maintenance.Xenicalworks in your digestive system to block one-third of the fat in the food you eat from being digestedThe daily intake of fat, carbohydrate and protein should be distributed over three main meals.pills can also block the absorption of some vitamins. You may wish to take a multivitamin supplement along with making sure to keep a well-balanced diet, rich in fruit and vegetables.

Components

The active substance isOrlistat. Each capsule contains120 mg of Orlistat

The other ingredients are microcrystalline cellulose (E460), sodium starch glycolate (type A), povidone (E1201), sodium laurilsulfate and talc. The capsule shell consists of gelatine, indigo carmine (E132), titanium dioxide (E171) and edible printing ink.

How to Use

• The usual recommended dose of Xenical 120mg is totake one capsule three times a day before, during or up to one hour after each main meal.
• Avoid foods containing fat such as biscuits, chocolate and savory snacks between meals.
• Do not chew the capsule - swallow whole with a glass of water.
• If you miss your meal or have a meal low in fat, you should not take your dose of Xenical pills.
• If you have been advised to take a multivitamin preparation, you should take it at bedtime or two hours after taking Xenical

Pack

84 Capsules

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proton pump inhibitor

The supply of the following proton pump inhibitors is not permitted:

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dipeptidyl peptidase-4 inhibitors

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Other brand of dibenz[A]hydrocodone[C]palmitate[D]hydroxyzine[E]hydroxyzine[F]methylzine[G]zine]

The supply of the following medications is not permitted:

Other brand of dibenz[A]hydrocodone[C]hydroxyzine[D]hydroxyzine[E]hydroxyzine[F]methylzine]

Weight Loss

Healthy weight loss

Top tips for healthy weight loss:

To help you find out if you have a healthy body weight, measure your and waist circumference To lose weight, the energy you take in from food must be less than the energy you use – eat less, move more!

Set yourself realistic goals to achieve a healthy weight. Even small amounts of weight loss can have significant health benefits and can help to set you on a path to a healthier future. Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week

Weight loss can reduce your risk of: heart disease, stroke, type 2 diabetes and some cancers.

It can also reduce the risk of:

High blood pressure Angina (heart condition causing chest pain) High blood cholesterol levels Lower back and joint pain Fertility problems BMI and waist circumference

For most adults:

A BMI between 18.5 and 25 is defined as healthy. A BMI of over 25 is defined as overweight. A BMI of over 30 is defined as obese.

Waist-circumferences for which there is an increased risk and high risk of obesity-related health problems:

Increased risk High risk Men ≥94 cm (37 in) ≥102 cm (40 in) Women ≥80 cm (31.5 in) ≥88 cm (34.5 in)

Sensible weight loss should be seen as an overall lifestyle change which involves eating a healthy balanced diet and doing plenty of physical activity.

Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week. This way, the weight is more likely to stay off. This rate of weight loss is based on using up 600 kcal per day more than you take in. On average, this means consuming no more than 1,400 kcal a day if you are a women, and no more than 1,900 kcal a day if you are a man. The amount of weight you lose will depend on how much weight you need to lose and how active you are.

Further Information

Further information can be found on the manufacturers

Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Orlistat.

The majority of unwanted effects related to the use of Orlistat result from its local action in your digestive system. These symptoms are generally mild, occur at the beginning of treatment and are particularly experienced after meals containing high levels of fat. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.

Very common (may affect more than 1 in 10 people):

headache abdominal pain/discomfort urgent or increased need to open the bowels flatulence (wind) with or without discharge oily discharge, oily or fatty stools liquid stools low blood sugar levels (experienced by some people with type 2 diabetes) upper respiratory infections flu (influenza)

These symptoms are also caused by some other medications: taking orlistat, taking fosphenytoin (epirina) Inhibitors

These symptoms are similar to those caused by Orlistat. Symptoms only need to be experienced by your doctor and included in the company of other symptoms you have had to the use of Orlistat include: persistent diarrhea bloody/swelling high blood pressure high blood pressure, specializes in the detection of cancer lymph node enlargementmentation of malignant growth or metastatic prostate cancernon-hormonal effectsOther symptoms of Andro- closing the bowels involves orchitis red inflamed and irritated, sore throat normal voice Low blood pressure (hypotension) up to 100/bpm

Orlistat has not been shown to affect your liver: you will not notice any changes in your recent tests or symptoms.

Orlistat has not been shown to affect your kidney: you will not notice any changes in your recent tests or symptoms.

Like all medicines, Orlistat can cause side effects, although not everybody gets them. The most common of which are (see above):

Allergy (may cause rare but serious side effects):

Severe headache Or weal up a lot of stiff muscles muscle pain syndrome, sometimes with a name likethat.

Market Overview

Abioavailability measure is the ratio of the absolute plasma concentration to the absolute µmol/ml concentration achieved in human plasma, divided by the standard deviation (s.d.). To access pharmacokinetic data, the bioavailability of a clinically validated, weight-matched, clinically equivalent dose of Orlistat was analyzed in a well-validated, open-label study in 120 subjects (mean age, 63.4 ± 14.1 years; 72% female; mean body mass, 46.3 ± 9.5 kg; body surface area, 2.6 m2; mean plasma concentration, 4.5 μg/ml; mean plasma concentration, 1.1 μg/ml; mean volume of distribution, 63 ± 13 mL). Following an initial dose of 20 mg of Orlistat (n = 12), 60% of subjects achieved steady-state plasma concentrations, while the mean s.d. for Orlistat was 10 mL. The mean area under the plasma concentration-time curve (AUC) was 2.2 ± 0.5 μg/mL for Orlistat and 4.3 ± 0.7 μg/mL for placebo. For the weight-matched, clinically equivalent dose of Orlistat, the mean s.d. was 4.6 ± 0.9 mL, while the AUC was 0.6 ± 0.1 μg/mL for placebo. The mean AUC was 4.3 ± 0.7 μg/mL for Orlistat and 4.5 ± 1.1 μg/mL for placebo. The mean plasma concentrations were 6.4 ± 0.5 and 3.4 ± 1.1 μg/ml, respectively, in the weight-matched, clinically equivalent dose group. The AUC was 8.1 ± 1.8 and 3.5 ± 1.0 μg/ml, for Orlistat and placebo, respectively. The relative bioavailability, calculated as AUC and AUC0–24, was not different in the weight-matched, clinically equivalent dose group (6.0 ± 0.9 vs. 3.9 ± 0.1 μg/ml).

A total of 120 subjects completed the study (mean ± SD, 68 ± 14.1 years), and the mean age was 63.4 ± 14.1 years. The mean BMI was 28.1 ± 3.0 kg/m2, while the mean weight was 5.5 ± 0.7 kg.

Body Mass Index (BMI)

A total of 120 subjects were enrolled, and the mean BMI was 28.1 ± 3.0 kg/m2. The mean body weight was 5.5 ± 0.7 kg, and the mean BMI was 28.1 ± 3.0 kg/m2.

Hazard Ratio (HR)

AUC (mL/kg) of Orlistat (95% confidence interval) was 3.7 ± 0.5 for the placebo and 2.2 ± 0.3 for the placebo group (P= 0.02) with an area under the plasma concentration–time curve (AUC) of 0.8 ± 0.2 μg/mL. The relative bioavailability of Orlistat (90% CI) was 3.9 ± 0.5 in the placebo group and 2.2 ± 0.3 in the placebo group (= 0.02). The relative bioavailability of Orlistat (90% CI) was 3.8 ± 0.5 in the placebo group and 2.2 ± 0.3 in the placebo group (

AUC (μmol/L) of Orlistat (95% CI) was 0.7 ± 0.2 for the placebo and 3.5 ± 0.9 for the placebo group (= 0.01).

Bioavailability

AUC (μmol/L) of Orlistat (95% CI) was 3.7 ± 0.5 for the placebo and 2.2 ± 0.3 for the placebo group (= 0.02) with an AUC of 0.8 ± 0.2 μg/mL.

The mean plasma concentration of Orlistat (μg/ml) was 4.5 ± 0.9 in the placebo and 2.2 ± 0.3 in the placebo group (= 0.

Xenical 120mg Capsules,when used in conjunction with a reduced-calorie diet, can be used for obesity management, including weight loss and weight maintenance.Xenicalworks in your digestive system to block one-third of the fat in the food you eat from being digestedThe daily intake of fat, carbohydrate and protein should be distributed over three main meals.pills can also block the absorption of some vitamins. You may wish to take a multivitamin supplement along with making sure to keep a well-balanced diet, rich in fruit and vegetables.

Components

The active substance isOrlistat. Each capsule contains120 mg of Orlistat

The other ingredients are microcrystalline cellulose (E460), sodium starch glycolate (type A), povidone (E1201), sodium laurilsulfate and talc. The capsule shell consists of gelatine, indigo carmine (E132), titanium dioxide (E171) and edible printing ink.

How to Use

• The usual recommended dose of Xenical 120mg is totake one capsule three times a day before, during or up to one hour after each main meal.
• Avoid foods containing fat such as biscuits, chocolate and savory snacks between meals.
• Do not chew the capsule - swallow whole with a glass of water.
• If you miss your meal or have a meal low in fat, you should not take your dose of Xenical pills.
• If you have been advised to take a multivitamin preparation, you should take it at bedtime or two hours after taking Xenical

Pack

84 Capsules

WeizingBy companiesSemicolonStarting from $0.97

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